BDBM484263 (S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)-5- methylimidazo[1,5-a]pyrazin-3- yl)pyrrolidin-1-yl)prop-2-en-1-one::US10933063, Compound 62::US10933063, Compound 84::US11554118, Compound 84

SMILES COc1cccc(Oc2ccc(cc2)-c2nc([C@@H]3CCCN3C(=O)C=C)n3c(C)cncc23)c1F

InChI Key InChIKey=NUUPFGWPWWKFJD-FQEVSTJZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 484263   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484263((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Affinity DataIC50:  30nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484263((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Affinity DataIC50: <10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484263((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Affinity DataIC50: <10nMAssay Description:Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were performed in a reaction volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticleUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Suzhou Baijibugong Pharmaceutical Technology

US Patent
LigandPNGBDBM484263((S)-1-(2-(1-(4-(2-fluoro-3- methoxyphenoxy)phenyl)...)
Affinity DataIC50:  30nMAssay Description:Btk and Other Kinases: Btk kinase activity was determined using a homogenous time resolved fluorescence (HTRF) methodology. Measurements were perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent