BDBM48449 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE::METHYLDOPA::MLS000028644::SMR000059170::cid_38853

SMILES C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O

InChI Key InChIKey=CJCSPKMFHVPWAR-JTQLQIEISA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 48449   

TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM48449(3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE | METHY...)
Affinity DataIC50:  8.08E+3nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM48449(3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE | METHY...)
Affinity DataIC50:  6.42E+4nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM48449(3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE | METHY...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM48449(3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE | METHY...)
Affinity DataIC50:  4.12E+4nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed