BDBM485778 (S)—N-Methyl-3-(quinolin-5-yloxy)-3-(thiazol-2-yl)propan-1-amine and (R)—N-methyl-3-(quinolin-5-yloxy)-3-(thiazol-2-yl)propan-1-amine::US10941138, Example 76::US10941138, Example 77

SMILES CNCC[C@H](Oc1cccc2ncccc12)c1nccs1

InChI Key InChIKey=BYXCBFNAGGVRKV-HNNXBMFYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 485778   

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM485778((S)—N-Methyl-3-(quinolin-5-yloxy)-3-(thiazol-2-yl)...)
Affinity DataKi:  300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM485778((S)—N-Methyl-3-(quinolin-5-yloxy)-3-(thiazol-2-yl)...)
Affinity DataKi:  1.75E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent