BDBM485788 (S)-3-(3-Fluorothiophen-2-yl)-3-(isoquinolin-8-yloxy)-N-methylpropan-1-amine and (R)-3-(3-fluorothiophen-2-yl)-3-(isoquinolin-8-yloxy)-N-methylpropan-1-amine::US10941138, Example 86::US10941138, Example 87
SMILES CNCC[C@H](Oc1cccc2ccncc12)c1sccc1F
InChI Key InChIKey=KNCJEJULKKTIEE-INIZCTEOSA-N
Data 6 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 485788
Affinity DataKi: 300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Human norepinephrine transporter (NET) enriched membranes (5 μg) were incubated with 5 nM of radiolabeled [3H]-Nisoxetin in assay buffer contain...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: 300nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: >3.00E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals
US Patent
Esteve Pharmaceuticals
US Patent
Affinity DataKi: >3.00E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair