BDBM486483 7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-((S)-1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-3,4-dihydro-2,6-naphthyridin-1(2H)-one Isomer 2::US10947234, Example 6
SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1
InChI Key InChIKey=GKHYUTBVGYQEFQ-ZEQRLZLVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 486483
Affinity DataIC50: 482nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+4nMAssay Description:The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair