BDBM486483 7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-((S)-1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-3,4-dihydro-2,6-naphthyridin-1(2H)-one Isomer 2::US10947234, Example 6

SMILES CC(=O)N1CCC(CC1)Nc1cc2C(=O)N(C[C@H](O)[C@@H]3Cc4ccccc4CN3)CCc2cn1

InChI Key InChIKey=GKHYUTBVGYQEFQ-ZEQRLZLVSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 486483   

TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486483(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataIC50:  482nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486483(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataEC50:  1.00E+4nMAssay Description:The PRMT5 TE assay is a biomarker assay for identifying compounds that inhibit symmetric dimethylation of arginine (SDMA) of PRMT5 substrates. This a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM486483(7-((1-acetylpiperidin-4-yl)amino)-2-(2-hydroxy-2-(...)
Affinity DataIC50:  1.00E+5nMAssay Description:PRMT5/MEP50 biochemical assay is a direct measurement of the methylation activity of the enzyme complex on a short peptide substrate derived from the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent