BDBM486556 30::US10947251, Example 29

SMILES [H][C@@]12CN(CC[C@@]1([H])N(C(=O)CO2)c1cc(F)c(cc1OC)-c1cccc(OC(F)(F)F)c1)S(=O)(=O)Nc1ccon1

InChI Key InChIKey=XXHDUUWMSHLIFT-WIYYLYMNSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 486556   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486556(30 | US10947251, Example 29)
Affinity DataIC50:  2.21nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM486556(30 | US10947251, Example 29)
Affinity DataIC50:  62.3nMAssay Description:Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent