BDBM488414 N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimidin-3-yl}-1H-indol-6-yl)acetamide::US10954241, Example 54::US11548896, Example 54

SMILES CC(=O)Nc1ccc2cc([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key InChIKey=BRONVRHOEUHJIF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488414   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  2.20nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  1.06E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  205nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  2.20nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  1.06E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488414(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  205nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent