BDBM488442 N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimidin-3-yl}-3-chloro-1H-indol-6- yl)acetamide::US10954241, Example 82

SMILES CC(=O)Nc1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key InChIKey=KBDSQCRPBRYMOP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488442   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488442(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  1.05E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488442(N-(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyri...)
Affinity DataIC50:  11.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent