BDBM488449 2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H-pyrazolo[3,4-d]pyrimidin-3-yl]-3-chloro-N- cyclopropyl-1H-indole-6-carboxamide::US10954241, Example 89::US11548896, Example 89

SMILES CS(=O)(=O)N1CCC(CC1)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(=O)NC2CC2)c2c(N)ncnc12

InChI Key InChIKey=SHDOSPHGKDEPQN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488449   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50:  4.73nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50:  646nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50:  8.72nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50:  4.73nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50:  646nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488449(2-[4-Amino-1-(1-methanesulfonylpiperidin-4-yl)- 1H...)
Affinity DataIC50:  8.72nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent