BDBM489170 (R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfonyl)phenyl) amino)pyrimidin-4- yl)-1H-indol-7- yl)butanamide::US10961228, Example 53

SMILES CC[C@@H](N1CCN(C)C[C@@H]1C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 489170   

TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM489170((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...)
Affinity DataIC50: <3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM489170((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...)
Affinity DataIC50: >3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM489170((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...)
Affinity DataIC50:  2.08E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent