BDBM492907 (S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)amino)-N-(thiazol-4-yl)pyridine-3-sulfonamide::US10981905, Example 1::US11639351, Example 1

SMILES C[C@H](Nc1ncc(cc1Cl)S(=O)(=O)Nc1cscn1)c1cc(Cl)ccc1F

InChI Key InChIKey=LHWVSGXBCTXNBH-VIFPVBQESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 492907   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492907((S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  2.82E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492907((S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  5.57E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492907((S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492907((S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  2.82E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492907((S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  5.57E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492907((S)-5-chloro-6-((1-(5-chloro-2-fluorophenyl)ethyl)...)
Affinity DataIC50:  5.00E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent