BDBM492973 5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino)-N-(6-fluoropyridin-2-yl)-4-methylthiophene-2-sulfonamide trifluoroacetic acid salt::US10981905, Example 43::US11639351, Example 43

SMILES Cc1cc(sc1NCc1c(F)cccc1CN1CCCC1)S(=O)(=O)Nc1cccc(F)n1

InChI Key InChIKey=CNXFHKQBWRBDAN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 492973   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492973(5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino...)
Affinity DataIC50:  2.11E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492973(5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino...)
Affinity DataIC50:  1.03E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492973(5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino...)
Affinity DataIC50:  8.21E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492973(5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino...)
Affinity DataIC50:  2.11E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492973(5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino...)
Affinity DataIC50:  1.03E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492973(5-((2-fluoro-6-(pyrrolidin-1-ylmethyl)benzyl)amino...)
Affinity DataIC50:  8.21E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent