BDBM492998 5-((2-((tert-butyl(methyl)amino)methyl)benzyl)amino)-3-fluoro-N-(isoxazol-3-yl)-6-methylpyridine-2-sulfonamide trifluoroacetic acid salt::US10981905, Example 46

SMILES CC(C)N(C)Cc1ccccc1CNc1cc(F)c(nc1C)S(=O)(=O)Nc1ccon1

InChI Key InChIKey=OODKKTOJIQYMDN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492998   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492998(5-((2-((tert-butyl(methyl)amino)methyl)benzyl)amin...)
Affinity DataIC50:  1.78E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492998(5-((2-((tert-butyl(methyl)amino)methyl)benzyl)amin...)
Affinity DataIC50:  3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492998(5-((2-((tert-butyl(methyl)amino)methyl)benzyl)amin...)
Affinity DataIC50:  3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent