BDBM497329 US11001595, Compound 3::US11111252, Compound 2

SMILES COc1cccc(Sc2sc3nc(N)nc(N)c3c2C)c1

InChI Key InChIKey=CFMWWZHVBLVEMM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 497329   

TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  177nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  624nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  252nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  1.41E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  970nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  5.63E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  1.60E+5nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  4.03E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Human pneumocystis pneumonia agent)
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  213nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University of The Holy Spirit

US Patent
LigandPNGBDBM497329(US11001595, Compound 3 | US11111252, Compound 2)
Affinity DataIC50:  1.04E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent