BDBM497329 US11001595, Compound 3::US11111252, Compound 2
SMILES COc1cccc(Sc2sc3nc(N)nc(N)c3c2C)c1
InChI Key InChIKey=CFMWWZHVBLVEMM-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 497329
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 177nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Affinity DataIC50: 624nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 252nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+3nMAssay Description:Table 7: The inhibitory activities of TMP and TMQ are listed for comparison. While the tested compounds displayed reduced potency against pjDHFR comp...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 5.63E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 1.60E+5nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 4.03E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Human pneumocystis pneumonia agent)
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Duquesne University of The Holy Spirit
US Patent
Duquesne University of The Holy Spirit
US Patent
Affinity DataIC50: 1.04E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair