BDBM498778 (1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]amino}-1H- pyrazol-5-yl)cyclopentyl (2$#958;)-2- ethyl-2-methylazetidine-1- carboxylate - Isomer A::US11014911, Example 603::US11014911, Example 604::US11718603, Example 604

SMILES CCC1(C)CCN1C(=O)O[C@@H]1CC[C@@H](C1)c1cc(NC(=O)Cc2cc(C)no2)n[nH]1

InChI Key

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 498778   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  0.0700nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  0.0700nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  0.0800nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  0.0800nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  5nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  5nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  13.8nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM498778((1R,3S)-3-(3-{[(3-methyl-1,2- oxazol-5-yl)acetyl]...)
Affinity DataKi:  13.8nMAssay Description:The purpose of GSK3β assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) of small molecule inhibitors by using a fluorescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent