BindingDB BDBM50002338 (Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine::10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine::10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine::10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine)::CHEMBL479::MELLARIL::MELLARIL-S::THIORIDAZINE::TP-21::US9504692, Thioridazine

BDBM50002338 (Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine::10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine::10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine::10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine)::CHEMBL479::MELLARIL::MELLARIL-S::THIORIDAZINE::TP-21::US9504692, Thioridazine

SMILES CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1

InChI Key InChIKey=KLBQZWRITKRQQV-UHFFFAOYSA-N

Data 126 KI 46 IC50 1 Kd 1 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50002338

D(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 4nMAssay Description:Displacement of [3H]-haloperidol from Dopamine receptor D2 in rat brainMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Adenosine receptor A1(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: >1.00E+4nMAssay Description:Displacement of [3H]-CHA (N6-Cyclohexyl adenosine) from adenosine A1 receptor receptor in rat brainMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Beta-1 adrenergic receptor(Rattus norvegicus (Rat))
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: >1.00E+4nMAssay Description:Displacement of [3H]-DHA (Dihydroalprenolol) from beta-1 adrenergic receptor in rat brainMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Beta-2 adrenergic receptor(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: >1.00E+4nMAssay Description:Displacement of [3H]-DHA (Dihydroalprenolol) from beta-2 adrenergic receptor in rat brainMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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D(1A) dopamine receptor(RAT)
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 80nMAssay Description:Displacement of [3H]-cis-flupenthixol from Dopamine receptor D1 in rat brainMore data for this Ligand-Target Pair

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Muscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 2nMAssay Description:Displacement of [3H]quinuclidinyl benzilate (QNB) from Muscarinic acetylcholine receptor in rat brainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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5-hydroxytryptamine receptor 1A/1B/1D/1F(RAT)
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 8.70E+3nMAssay Description:Displacement of [3H]-5-HT from serotonin-1 neurotransmitter receptor in rat brainMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 17nMAssay Description:Displacement of [3H]WB-4101 from alpha-1 adrenergic receptor in rat brainMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 1.30E+3nMAssay Description:Displacement of [3H]clonidine from alpha-2 adrenergic receptor in rat brainMore data for this Ligand-Target Pair

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Serotonin 2 (5-HT2) receptor(RAT)
Warner-Lambert

Curated by ChEMBL

BDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)

IC50: 60nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor as antagonism of serotonin-induced contractions in rat jugular veinMore data for this Ligand-Target Pair

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Filter my 174 hits

Targets 46▿
- D(2) dopamine receptor 40
- D(1A) dopamine receptor 13
- Potassium voltage-gated channel subfamily H member 2 12
- Alpha-1A adrenergic receptor 9
- 5-hydroxytryptamine receptor 2A 9
- D(4) dopamine receptor 6
- Histamine H1 receptor 6
- 5-hydroxytryptamine receptor 2C 5
- Muscarinic acetylcholine receptor M2 5
- Voltage-dependent L-type calcium channel subunit alpha-1C 5
- 5-hydroxytryptamine receptor 7 5
- D(3) dopamine receptor 4
- 5-hydroxytryptamine receptor 6 4
- Alpha-2A adrenergic receptor 4
- Alpha-2C adrenergic receptor 3
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 3
- Muscarinic acetylcholine receptor M3 3
- Mucosa-associated lymphoid tissue lymphoma translocation protein 1 2
- Alpha-2B adrenergic receptor 2
- Muscarinic acetylcholine receptor M5 2
- 5-hydroxytryptamine receptor 1A 2
- Muscarinic acetylcholine receptor M1/M2/M3/M4/M5 2
- Muscarinic acetylcholine receptor M4 2
- Serotonin 2 (5-HT2) receptor 2
- Muscarinic acetylcholine receptor M1 2
- Beta-2 adrenergic receptor 2
- Pleiotropic ABC efflux transporter of multiple drugs 1
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1F/alpha-1S 1
- Sigma non-opioid intracellular receptor 1 1
- Proteasome subunit alpha type-6 1
- Replicase polyprotein 1ab 1
- Albumin 1
- Sodium channel protein type 5 subunit alpha 1
- Glutathione S-transferase P/Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1
- Alpha-1B adrenergic receptor 1
- Adenosine receptor A1 1
- Beta-1 adrenergic receptor 1
- Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 1
- Gamma-aminobutyric acid receptor subunit gamma-1 1
- D(1B) dopamine receptor 1
- Broad substrate specificity ATP-binding cassette transporter ABCG2 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- Bile salt export pump 1
- D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor 1
- ...
Publications 50▿
- Acta Pharmacol Toxicol (Copenh) 58: 61-70 (1986) 12
- Neuropsychopharmacology 28: 519-26 (2003) 12
- J Med Chem 31: 454-61 (1988) 10
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- Mol Pharmacol 12: 800-12 (1976) 7
- J Med Chem 29: 359-69 (1986) 6
- Eur J Pharmacol 291: 59-66 (1995) 6
- J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) 5
- J Pharmacol Exp Ther 260: 576-80 (1992) 5
- Prog Neuropsychopharmacol Biol Psychiatry 27: 1125-43 (2003) 5
- J Pharmacol Exp Ther 268: 1403-10 (1994) 5
- Eur J Pharmacol 103: 197-204 (1984) 5
- Mol Psychiatry 3: 123-34 (1998) 4
- Eur J Med Chem 201: (2020) 4
- Eur J Pharmacol 347: 301-9 (1998) 4
- Psychopharmacology (Berl) 120: 365-8 (1995) 3
- Pharmacol Rev 53: 119-33 (2001) 3
- J Med Chem 30: 1807-12 (1987) 3
- J Pharmacol Exp Ther 259: 323-9 (1991) 3
- J Med Chem 35: 4516-25 (1993) 3
- Cardiovasc Res 91: 53-61 (2011) 3
- Neuropsychopharmacology 16: 93 (1997) 3
- Eur J Pharmacol 450: 37-41 (2002) 3
- Br J Pharmacol 130: 692-8 (2000) 2
- J Pharmacol Exp Ther 237: 731-8 (1986) 2
- Mol Pharmacol 13: 454-73 (1977) 2
- J Pharmacol Exp Ther 260: 1361-5 (1992) 2
- J Med Chem 46: 2017-22 (2003) 2
- Nature 350: 610-4 (1991) 2
- Life Sci 35: 1885-93 (1984) 2
- Eur J Pharmacol 236: 483-6 (1993) 2
- J Pharmacol Exp Ther 315: 1278-87 (2005) 2
- Nature 347: 146-51 (1990) 2
- Life Sci 37: 1971-83 (1985) 2
- J Appl Toxicol 32: 858-66 (2012) 2
- Nature 350: 614-9 (1991) 2
- J Med Chem 46: 2795-812 (2003) 1
- Eur J Med Chem 46: 618-30 (2011) 1
- Bioorg Med Chem Lett 15: 2886-90 (2005) 1
- Bioorg Med Chem Lett 16: 5303-8 (2006) 1
- J Med Chem 45: 3844-53 (2002) 1
- J Med Chem 26: 194-203 (1983) 1
- Sci Rep 3: (2013) 1
- Antimicrob Agents Chemother 64: (2020) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- Drug Metab Dispos 39: 312-21 (2011) 1
- J Pharmacol Exp Ther 295: 226-32 (2000) 1
- Synapse 25: 137-46 (1997) 1
- J Med Chem 64: 9217-9237 (2021) 1
- J Med Chem 52: 4266-76 (2009) 1
- ...
Institutions 35▿
- TBA 22
- Case Western Reserve University 20
- University of Toronto 18
- Mayo Clinic 17
- Astra LÄKemedel 12
- Warner-Lambert 10
- Aventis Pharmaceuticals 5
- Eli Lilly 5
- Uppsala University 4
- University Of Perugia 4
- Bristol-Myers Squibb 3
- Warner-Lambert/Parke-Davis Pharmaceutical Research 3
- University of Reading 3
- University of Nebraska 3
- University Of Oxford 3
- Schering-Plough 2
- U. 109 2
- Friedrich-Schiller-University Jena 2
- Stanford University 2
- Johns Hopkins University 2
- UniversitÉ 2
- Maryland Psychiatric Research Center 2
- Acadia Pharmaceuticals 2
- Jagiellonian University 2
- University Of Bologna 1
- Glaxosmithkline 1
- Tcg Lifesciences 1
- Novo Nordisk 1
- Astrazeneca 1
- Chantest 1
- Albany Medical College 1
- Virginia Commonwealth University 1
- Chinese Academy Of Sciences 1
- Reverse Proteomics Research Institute 1
- Institut Pasteur Korea 1
- ...
Affinity: 0.40 to 2.4E+4 nM▿
- Ki 126
- IC50 46
- Kd 1
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1