BDBM50005363 (3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane::(3R,4S)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane::(3S,4S)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane::3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2.2.1]heptane::CHEMBL92421

SMILES Cc1noc(n1)C1CN2CCC1C2

InChI Key InChIKey=JRYHRRQEXVCFPV-UHFFFAOYSA-N

Data  1 KI  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50005363   

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Astra Arcus Usa

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor using [3H]-OXO-M as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  2.40nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  3.30nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  16nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  2.40nMAssay Description:In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  7nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  7nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  16nMAssay Description:In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed