BDBM50007745 CHEMBL3233785

SMILES Fc1ccc(Nc2ncnc3sc(NC(=O)\C=C\CN4CC5CCC4C(=O)C5)cc23)cc1Cl

InChI Key InChIKey=WDQXCAKHPJSZET-OWOJBTEDSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50007745   

TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50:  30nMAssay Description:Inhibition of ErbB2 (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant ErbB4 (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant RET (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant Flt-1 (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KDR (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant c-Kit (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant PDGFRbeta (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant ABL (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant EPHA2 (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of wild type EGFR domain (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 substrate after 60 mins by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant RON (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50007745(CHEMBL3233785)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant PDGFRalpha (unknown origin) using Poly(Glu:Tyr)4:1 after 60 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed