BDBM50007791 CHEMBL3233815::med.21724, Compound 168

SMILES C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12

InChI Key InChIKey=XJTWGMHOQKGBDO-GOSISDBHSA-N

Data  7 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50007791   

TargetUbiquitin carboxyl-terminal hydrolase 8(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP8 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 20(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human USP20 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 21(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50: >3.10E+4nMAssay Description:Inhibition of human USP21 using Ub-rhodamine 110 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Mazandaran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50:  1.75E+3nMAssay Description:Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using Ub-Rho as substrate incubated for 5 mins by enzymatic assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1a(Human SARS coronavirus (SARS-CoV))
University of Bonn

LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50:  150nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
Mazandaran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50:  2.64E+3nMAssay Description:Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) using HCC-RLRGG-NH(CH2)4NH-DABCYL probe as substrate incubated for...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a(Human coronavirus NL63)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50007791(CHEMBL3233815 | med.21724, Compound 168)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of human coronavirus NL63 PLP2 (amino acids 1565 to 1894) expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of AMC rele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed