BDBM50011564 CHEMBL3262583::MAP10::US9592235, Example 158::US9855269, Compound 1

SMILES Nc1ncnc2ccc(cc12)-c1cccc(Cl)c1

InChI Key InChIKey=NFVSMRPXCHVTAG-UHFFFAOYSA-N

Data  1 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50011564   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50011564(CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...)
Affinity DataKi:  108nM IC50:  92.7nMAssay Description:Z'Lyte AssayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50011564(CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...)
Affinity DataIC50:  92.7nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50011564(CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...)
Affinity DataIC50:  92.7nMAssay Description:The kinase activity of purified human MAP4K4 kinase domain was measured by monitoring the phosphorylation of a peptide substrate derived from moesin ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM50011564(CHEMBL3262583 | MAP10 | US9592235, Example 158 | U...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human MAP4K4 using 5-FAM-LGRDKYKTLRQIRQ-COOH as substrate by Z'-LYTE assayMore data for this Ligand-Target Pair