BDBM50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine)::CHEMBL94739::Femoxetine

SMILES COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1

InChI Key InChIKey=OJSFTALXCYKKFQ-YLJYHZDGSA-N

Data  27 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50014247   

TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  9.08nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  9.10nMAssay Description:Tested in vitro for serotonin(5-HT) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  120nMAssay Description:Tested in vitro for norepinephrine (NE) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNorepinephrine transporter(RAT)
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  121nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(MOUSE)
Mcneil Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  1.04E+3nMAssay Description:Tested in vitro for dopamine(DA) neuronal uptake inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Mcneil Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50014247((3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phe...)
Affinity DataKi:  1.04E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed