BDBM50014434 CHEMBL3261427

SMILES C[C@@H](CNc1cccc2n(ncc12)-c1ccc(cc1)C#N)NS(=O)(=O)c1c(C)nn(C2CCCC2)c1C

InChI Key InChIKey=MKMJTAAVJXMHJQ-SFHVURJKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50014434   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50014434(CHEMBL3261427)
Affinity DataIC50:  16nMAssay Description:Agonist activity at glucocorticoid receptor in human Chago K1 cells assessed as gene transrepression by Lac-Z reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50014434(CHEMBL3261427)
Affinity DataIC50:  13nMAssay Description:Agonist activity at glucocorticoid receptor in human PBMC assessed as inhibition of LPS-stimulated TNF-alpha releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50014434(CHEMBL3261427)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to human glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed