BDBM50015266 CHEMBL3263053
SMILES CN(C)CC[C@@H](c1ccccc1)n1cc(NC(=O)c2n[nH]c3cc(ccc23)-c2cn[nH]c2)cn1
InChI Key InChIKey=NCXHAHGMYXETMO-QHCPKHFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50015266
Affinity DataKi: 0.100nMAssay Description:Inhibition of full-length ITK (unknown origin) using biotin-EQEDEPEGIYGVLF-NH2 as substrate by plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibition of GST-tagged full length ITK (unknown origin) using BLK peptide as substrate after 35 minsMore data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:Inhibition of human His-tagged full length AURKA using kemptide peptide as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as reduction in PLC-gamma phosphorylation after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 173nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as decrease in phosphorylation of PLC-gamma1 by immunodetection assayMore data for this Ligand-Target Pair