BDBM50016703 2-Hydroxymethyl-pyrrolidine-3,4-diol::BDBM50031485::CHEMBL80254::Imino-D-Arabinitol

SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O

InChI Key InChIKey=OQEBIHBLFRADNM-UHFFFAOYSA-N

Data  5 KI  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50016703   

TargetLysosomal alpha-glucosidase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of rat intestinal maltase assessed as release of D-glucose using maltose as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucoamylase, intracellular sporulation-specific(Baker's yeast)
University of Upper Alsace

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 150nMAssay Description:Inhibition of yeast alpha-D-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of rat intestinal maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of rat sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of rat isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen debranching enzyme(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGlycogen debranching enzyme(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of amylo-1,6-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human lysosomal acid alpha-glucosidase incubated for 30 mins by fluorescence based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of rat intestinal sucrase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAlpha-mannosidase(Jack bean)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 3.20E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase assessed as release of p-nitrophenol using p-nitrophenyl glycoside as substrate by spectrometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of rat small intestinal maltase assessed as reduction of D-glucose release using maltose as substrate by colorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of rat small intestinal sucrase assessed as reduction of p-nitrophenol release using p-nitrophenyl-glycoside as substrate by spectrophotom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMaltase-glucoamylase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human lysosomal alpha-glucosidase assessed as reduction of p-nitrophenol release using p-nitrophenyl-glycoside as substrate by spectrop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-mannosidase(Jack bean)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 4.74E+5nMAssay Description:Inhibition of jack bean alpha-mannosidase assessed as reduction of p-nitrophenol release using p-nitrophenyl-glycoside as substrate by spectrophotome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of yeast alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGlycogen phosphorylase, liver form(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetGlycogen phosphorylase, liver form(Rat)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2016
Entry Details Article
PubMed
TargetBeta-mannosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 2.90E+5nMAssay Description:Inhibition of rat epididymis beta-mannosidase assessed as p-nitrophenol release by spectrophotometricallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of rat intestinal isomaltase assessed as glucose release by Glucose B-testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of rat intestinal sucrase assessed as glucose release by Glucose B-testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of rat intestinal maltase assessed as glucose release by Glucose B-testMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-glucosidase MAL62(Baker's yeast)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 840nMAssay Description:Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometricallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-mannosidase 2C1(Rat)
Csiro Division of Chemicals and Polymers

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-mannosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of lysosomal Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrehalase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLactase/phlorizin hydrolase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 2.60E+5nMAssay Description:Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 3.40E+5nMAssay Description:Inhibition of human lysosomal acid beta-glucosidase incubated for 30 mins by fluorescence based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen phosphorylase, liver form(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataKi:  400nMAssay Description:Inhibitory activity against pig Liver glycogen phosphorylase aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGlycogen phosphorylase, muscle form(Rabbit)
Claude Bernard University Lyon 1

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataKi:  400nMAssay Description:Inhibition of rabbit muscle glycogen phosphorylase using tritium-labeled glycogen as substrate by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2017
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataKi:  1.40E+4nMAssay Description:Binding affinity to human lysosomal acid alpha-glucosidase assessed as inhibition constant incubated for 30 mins by fluorescence based spectrophotome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetAlpha-mannosidase 2(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataKi:  3.50E+4nMAssay Description:Competitive Inhibitory activity against Golgi Alpha-mannosidase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50016703(CHEMBL80254 | Imino-D-Arabinitol | BDBM50031485 | ...)
Affinity DataKi:  1.15E+5nMAssay Description:Competitive inhibition of recombinant human lysosomal alpha-glucosidase assessed as inhibition constant by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed