BDBM50020883 (R)-Piperidine-3-carboxylic acid::(R)-nipecotic acid::CHEMBL77575::Nipecotic acid
SMILES OC(=O)[C@@H]1CCCNC1
InChI Key InChIKey=XJLSEXAGTJCILF-RXMQYKEDSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50020883
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 5.96E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Rat)
Synaptic Pharmaceutical
Curated by ChEMBL
Synaptic Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical
Curated by ChEMBL
Synaptic Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent betaine transporter(Human)
Synaptic Pharmaceutical
Curated by ChEMBL
Synaptic Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.31E+6nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 9.99E+7nMAssay Description:Inhibition of [3H]GABA uptake at GAT2 in mouse astrocytes after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 1.07E+7nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 8.70E+6nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 4.07E+7nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 2.45E+8nMAssay Description:Inhibition of [3H]GABA uptake at GAT2 in mouse neurons after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT2 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.63E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.63E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.86E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 1.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.74E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.63E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.56E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.78E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.74E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 2.74E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 8.15E+4nMAssay Description:Inhibition of GAT1 transport activityMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 4.56E+5nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 1.07E+7nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 8.70E+6nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 4.07E+7nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent betaine transporter(Mouse)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 2.45E+8nMAssay Description:Inhibition of [3H]GABA uptake at GAT2 in mouse neurons after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Budapest University of Technology and Economics
Curated by ChEMBL
Budapest University of Technology and Economics
Curated by ChEMBL
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of mouse GAT1 assessed as reduction in GABA uptakeMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Human)
Synaptic Pharmaceutical
Curated by ChEMBL
Synaptic Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair