BDBM50021656 BARICITINIB::INCB-028050::LY-3009104::US10112907, Example 00034::US10766894, Compound TABLE 1.19::US10875847, Compound Baricitinib::US11203595, TABLE 1.19::US11414413, Example Baricitinib::US20230416237, Example baricitinib

SMILES CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12

InChI Key InChIKey=XUZMWHLSFXCVMG-UHFFFAOYSA-N

Data  77 IC50  11 Kd

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50021656   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of recombinant JAK1 (837 to 1142 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of recombinant JAK2 (828 to 1132 residues) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to AAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataKd:  20nMAssay Description:Binding affinity to BIKE (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataKd:  120nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed