BDBM50025150 2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-methyl-benzoylamino}-pentanedioic acid::CHEMBL342302

SMILES Cc1cc(ccc1C(=O)NC(CCC(O)=O)C(O)=O)N(CC#C)Cc1ccc2nc(N)[nH]c(=O)c2c1

InChI Key InChIKey=QXYWKDBPARNGDQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50025150   

TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025150(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataIC50:  19nMAssay Description:Compound was evaluated in vitro for the inhibition of L1210 thymidylate synthase with CB3717 as controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025150(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataIC50:  400nMAssay Description:Compound was evaluated in vitro for the inhibition of L1210 thymidylate synthase with CB3717 as controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50025150(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Affinity DataIC50:  2.50E+4nMAssay Description:The compound was evaluated in vitro for inhibition of purified L1210 dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed