BDBM50027433 CHEMBL603370::GR-89696

SMILES COC(=O)N1CCN(C(CN2CCCC2)C1)C(=O)Cc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=HJUAKZYKCANOOZ-UHFFFAOYSA-N

Data  4 KI  5 IC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50027433   

TargetMu-type opioid receptor(Homo sapiens (Human))
Wilhelms-Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataKi:  0.360nMAssay Description:Displacement of [(3)H]U69593 from mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]-U-69593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation countingMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]-U69593 from KOR in guinea pig brain membranes measured by competitive radioligand receptor binding assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataKi:  360nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0180nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0410nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Mercachem

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0410nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro inhibitory activity against delta specific tissue of hamster vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed