BDBM50032671 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID::6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-nicotinic acid::CHEMBL288436

SMILES Cc1cc2c(cc1C1(CC1)c1ccc(cn1)C(O)=O)C(C)(C)CCC2(C)C

InChI Key InChIKey=SLXTWXQUEZSSTJ-UHFFFAOYSA-N

Data  22 KI  2 IC50  3 Kd  10 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50032671   

TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  4nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  161nMAssay Description:In vitro agonist efficacy against PPAR gamma along with 100 nM BRL49653More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  19nMAssay Description:In vitro anatagonist activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  17nMAssay Description:In vitro agonistic activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  38nMAssay Description:Transcriptional activity against RXR:PPAR-gamma synergy was determined in vitroMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  11nMAssay Description:Inhibition of Retinoic acid receptor RXR-alpha agonist activity in vitroMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-gamma(Mus musculus)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  4nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  40nMAssay Description:Activation of human RXRalpha activity expressed in COS1 cells after 12 hrs by RXRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(RAT)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  11nMAssay Description:In vitro transcriptional activation in CV-1 cells expressing RXR-alphaMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-beta(Mus musculus)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032671(6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPH...)
Affinity DataEC50:  3nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.More data for this Ligand-Target Pair