BDBM50032675 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid::BEXAROTENE::CHEMBL1023::p-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid
SMILES Cc1cc2c(cc1C(=C)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
InChI Key InChIKey=NAVMQTYZDKMPEU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 57 hits for monomerid = 50032675
Affinity DataEC50: 20nMAssay Description:Inhibition of [3H]-ATRA binding to retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 28nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 33nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 33nMAssay Description:Effective concentration against retinoid receptor isoform (RXR alpha) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Effective concentration against retinoid receptor isoform (RXR beta) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay.More data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Effective concentration against Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 112nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
Affinity DataEC50: 122nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Effective concentration against retinoid receptor isoform (RXR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against retinoid receptor isoform (RAR beta) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against retinoid receptor isoform (RAR alpha) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Effective concentration against retinoid receptor isoform (RAR gamma) expressed in CV-1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after ...More data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Transcriptional activation in CV-1 cells expressiing Retinoic acid receptor RAR alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 648nMAssay Description:Transcriptional activation in CV-1 cells expressiing Retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 282nMAssay Description:Transcriptional activation in CV-1 cells expressiing Retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Transcriptional activity was evaluated in CV-1 cells transfected with expression vector for Retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at RXRalpha (unknown origin) expressed in COS1 cells incubated for 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 118nMAssay Description:Agonist activity at RXRalpha LBD (unknown origin) expressed in CV1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assayMore data for this Ligand-Target Pair
Affinity DataEC50: 32nMAssay Description:Agonist activity at histidine-tagged ligand binding domain of human RXRalpha expressed in Escherichia coli BL21 (DE3) by luciferase reporter gene ass...More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Transactivation of Gal4-LBD fused mouse RXRalpha (218 to 467) transfected in african green monkey CV1 cells assessed as luciferase activity at after ...More data for this Ligand-Target Pair
Affinity DataEC50: 52nMAssay Description:Agonist activity at human recombinant Gal4-tagged RXRalpha expressed in human Caco2 cells assessed as receptor homodimerization after 24 hrs by mamma...More data for this Ligand-Target Pair
Affinity DataEC50: 19.8nMAssay Description:Agonist activity at RXRalpha by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at RXRalpha transfected in human COS1 cells after 18 hrs by luciferase reporter gene transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at RXRalpha in rat RK3E cells assessed as transcriptional activation by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.70nMAssay Description:Agonist activity at human RXRalpha LBD by cell based luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Effective potency in transcriptional activation assay in CV-1 cells expressing Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataEC50: 434nMAssay Description:Partial agonist activity at recombinant human GAL4-DBD-fused LXRbeta-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo luciferas...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataEC50: 196nMAssay Description:Partial agonist activity at recombinant human GAL4-DBD-fused LXRalpha-LBD expressed in HEK293T cells measured after 12 to 14 hrs by dual-glo lucifera...More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity at RXRgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RARbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Agonist activity at RXRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 33nMAssay Description:Agonist activity at RXRaplha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RARgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at RARaplha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 149nMAssay Description:Transactivation of human RXRalpha transfected in human 293 cells after 48 hrs by dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 33nMAssay Description:Agonist activity RXRalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:Agonist activity RXRgamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 24nMAssay Description:Agonist activity RXRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at human RXRalpha expressed in African green monkey COS1 cells harboring CRBP2-tk-luc reporter incubated for 18 hrs by steady-glo lu...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair