BDBM50035398 (S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidinium::(S)-3-methyl-5-(1-methylpyrrolidin-2-yl)isoxazole::3-Methyl-5-((S)-1-methyl-pyrrolidin-2-yl)-isoxazole::ABT-418::CHEMBL274525

SMILES CN1CCC[C@H]1c1cc(C)no1

InChI Key InChIKey=ILLGYRJAYAAAEW-QMMMGPOBSA-N

Data  53 KI  3 IC50  11 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50035398   

TargetNicotinic acetylcholine receptor(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi:  3nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi:  7.90nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi:  4.05E+3nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [125I]-alpha-bungarotoxin from K-28 cells stably express human Nicotinic...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Target5-hydroxytryptamine receptor 1A/1B/1D/2C(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Target5-hydroxytryptamine receptor 2A(PIG)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetAdenosine receptor A1(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetAdenosine receptor A2a(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
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TargetAdenylate cyclase type 9(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetSolute carrier family 22 member 1(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoReactome pathway
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TargetAdrenergic alpha2 receptor(Mesocricetus auratus)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
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TargetBeta-2 adrenergic receptor(Mus musculus)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetChloride channel protein 1(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetMuscarinic acetylcholine receptor M1(Mus musculus)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
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TargetD(1A) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetD(2) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
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TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetGamma-aminobutyric acid type B receptor subunit 1(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetGlutamate receptor 3(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetGlutamate receptor ionotropic, kainate 2(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetGLRA1 protein(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/TrEMBL
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TargetGLRA1 protein(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/TrEMBL
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TargetHistamine H1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetInositol-tetrakisphosphate 1-kinase(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetNicotinic acetylcholine receptor(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
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TargetNicotinic acetylcholine receptor(RAT)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/TrEMBL
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TargetSubstance-P receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetSubstance-K receptor(Bos taurus)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetBeta-nerve growth factor(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
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TargetApamin(Apis mellifera (Honeybee))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
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TargetProtein kinase C(Drosophila melanogaster (Fruit fly))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoReactome pathway
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TargetOuter capsid protein sigma-1(Mammalian orthoreovirus 3 Dearing)
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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TargetVIP peptides(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP K_i Database

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brainMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+4nMAssay Description:Binding potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataEC50:  6.40E+4nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataEC50:  1.00E+4nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataEC50:  6.00E+3nMAssay Description:Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetAcetylcholine receptor subunit delta(Torpedo californica)
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataEC50:  4.11E+5nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle)More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
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TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataEC50:  2.64E+5nMAssay Description:Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic)More data for this Ligand-Target Pair

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TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Torpedo californica)
Abbott Laboratories

Curated by ChEMBL

LigandBDBM50035398((S)-1-Methyl-2-(3-methyl-isoxazol-5-yl)-pyrrolidin...)Copy SMILESCopy InChI

Affinity DataEC50:  4.11E+5nMAssay Description:Binding potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

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