BDBM50040030 4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (2)::CHEMBL3318415

SMILES OC1=C(Sc2ccccc2Cl)C(=O)CC(C1)c1ccccc1

InChI Key InChIKey=ZUUIXGIFVWOUQU-UHFFFAOYSA-N

Data  9 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50040030   

TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50:  4.60E+3nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50:  1.90E+4nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human LDH-A by biochemical assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataKd:  4.30E+3nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50040030(4-((2-chlorophenyl)thio)-5-hydroxy-1,6-dihydro-[1,...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed