BDBM50042498 CHEMBL333219::N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea

SMILES CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1

InChI Key InChIKey=SOEOWQASEQWFFZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50042498   

TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50:  410nMAssay Description:Inhibitory concentration against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50:  410nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibitory concentration against human platelet thromboxane synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50:  45nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50:  51nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Ovis aries (Sheep))
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(CHEMBL333219 | N-{[6-(4-fluorophenoxy)-2H-chromen-...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed