BDBM50042982 2',3,4-trihydroxychalcone::3-(3,4-Dihydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone::CHEMBL339587::US11866416, Compound 4::cid_5709318

SMILES Oc1ccc(\C=C\C(=O)c2ccccc2O)cc1O

InChI Key InChIKey=PSYVAIWGYVDYHN-FNORWQNLSA-N

Data  5 IC50  1 Kd  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50042982   

TargetZinc finger protein mex-5(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataEC50:  4.23E+4nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPOsterior Segregation(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataEC50:  3.00E+5nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetLarge T antigen(Simian virus 40)
Southern Research Specialized Biocontainment Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataEC50:  2.63E+4nMAssay Description:Southern Research's Specialized Biocontainment Screening Center (SRSBSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Librarie...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataIC50:  6.10E+4nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyocilin(Homo sapiens)
Georgia Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataKd:  99nMAssay Description:Binding affinity myocilin-OLF domain (unknown origin) by Sypro Orange dye-based DSF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataIC50:  3.56E+5nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042982(2',3,4-trihydroxychalcone | 3-(3,4-Dihydroxy-pheny...)
Affinity DataIC50:  23nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article