BDBM50043280 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid::4'-((4-methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid::4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid::4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid::4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid::BIBR 277::CHEMBL1017::TELMISARTAN

SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C

InChI Key InChIKey=RMMXLENWKUUMAY-UHFFFAOYSA-N

Data  8 KI  31 IC50  1 Kd  18 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50043280   

TargetPeroxisome proliferator-activated receptor delta(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse PPARdelta expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mouse PPARalpha expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human PPARdelta expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human PPARalpha expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.06E+3nMAssay Description:Agonist activity at mouse PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  2.02E+3nMAssay Description:Agonist activity at human PPARgamma expressed in african green monkey CV1 cells by Gal4 transactivation assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  3.40E+3nMAssay Description:Activation of Gal4-tagged human PPARgamma expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  1.52E+3nMAssay Description:Partial agonist activity at human PPARgamma-LBD/Gal4 DNA binding domain by transactivation assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.71E+3nMAssay Description:Transactivation at Gal4 fused PPARgamma LBD (unknown origin) expressed in African green monkey COS7 cells after 42 hrs by luciferase assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.70E+3nMAssay Description:Transactivation of GAL4-fused human PPARgamma ligand binding domain expressed in African green monkey COS7 cells after 42 hrs by dual luciferase repo...More data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  700nMAssay Description:Displacement of Fluoromone from GST-tagged recombinant human PPARgamma ligand binding domain by LanthaScreen TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  1.52E+3nMAssay Description:Partial agonist activity at human PPARgamma-LBD/Gal4 DNA binding domain by transactivation assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.97E+3nMAssay Description:Transactivation of Gal4 fused human PPARgamma LBD expressed in African green monkey COS7 cells after 42 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.28E+3nMAssay Description:Transactivation of Gal4-fused human PPARgamma transfected in COS7 cells co-transfected with pGAL5-TK-pGL3 and pRennilla-CMV incubated for 39 hrs by d...More data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  2.02E+3nMAssay Description:Transactivation of GAL4-tagged human PPARgamma expressed in African green monkey COS7 cells after 36 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.30E+3nMAssay Description:Agonist activity at human PPARgammaDEF receptor expressed in african green monkey COS7 cells transfected with pGal5-TK-pGL3/pRenilla-CMV assessed as ...More data for this Ligand-Target Pair
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  4.50E+3nMAssay Description:Activity at full length human PPARgamma transfected in CV1 cells assessed as transactivation activity after 24 hrs by PPRE-TK- luciferase reporter ge...More data for this Ligand-Target Pair
TargetGlycine receptor subunit alpha-1(Homo sapiens (Human))
University Of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataEC50:  3.20E+3nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed