BDBM50044666 CHEMBL3353340::US10358436, Example A22
SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccncc3)n[nH]c2c1
InChI Key
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50044666
Affinity DataIC50: 30nMAssay Description:Inhibition of CYP2C9 (unknown origin) using MFC substrate after 45 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of KDR (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of FLT3 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Inhibition of AURKB (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of CYP2C19 (unknown origin) using MFC substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of CYP2D6 (unknown origin) using AMMC substrate after 45 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK4 [1-391](Homo sapiens (Human))
University Health Network
US Patent
University Health Network
US Patent
Affinity DataIC50: <100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin) using CEC substrate after 15 mins by fluorescence assayMore data for this Ligand-Target Pair