BDBM50048710 CHEMBL3319485

SMILES CC(Nc1cccc(Cl)c1F)c1cc(cn2c1nc(cc2=O)N1CCOCC1)C(=O)NCCN(C)C

InChI Key InChIKey=GOYGSVJFUAFYBM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048710   

LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  92nMAssay Description:Inhibition of human recombinant PI3Kalpha assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant PI3Kbeta assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kbeta in human MAD-MB-468 cells assessed as inhibition of Ser473 Akt phosphorylation by cellular potency assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  51nMAssay Description:Inhibition of human recombinant PI3Kdelta assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  970nMAssay Description:Inhibition of PI3Kalpha in human BT474 cells assessed as inhibition of Tyr308 Akt phosphorylation after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048710(CHEMBL3319485)
Affinity DataIC50:  670nMAssay Description:Inhibition of human recombinant PI3Kgamma assessed as depletion of ATP substrate by Ultra Glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed