BDBM50048864 CHEMBL3310505
SMILES [H][C@@]12CC(=O)N[C@H](C(C)C)C(=O)N[C@]([H])(CSSCC\C=C\1)C(=O)N\C(=C/C)C(=O)N[C@@H](C(C)C)C(=O)O2
InChI Key InChIKey=OHRURASPPZQGQM-QSVHVVLASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 50048864
Affinity DataIC50: 1nMAssay Description:Inhibition of human HDAC1 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreito...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC8 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human HDAC1More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human HDAC6More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of HDAC in human HeLa nuclear extractMore data for this Ligand-Target Pair
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
Curated by ChEMBL
Dipartimento Di Chimica E Tecnologie Del Farmaco "Sapienza" Universit£
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC1 in Plasmodium falciparum 3D7 nuclear extract using Ac-RGK(Ac)-AMC fluorogenic peptide as substrate preincubated for 1 hr followed...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition an...More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of PAK1 in v-Ha-RAS-transformed mouse NIH/3T3 cells incubated for 48 hrs by immunoblot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Pak Research Center
Curated by ChEMBL
Pak Research Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of PAK1 in estrogen-stimulated human MCF7 cells incubated for 48 hrs by immunoblot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of HADC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of HADC2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of HADC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
TargetProtein Tat(Human immunodeficiency virus type 1 (isolate HXB2 ...)
The Walter And Eliza Hall Institute For Medical Research
Curated by ChEMBL
The Walter And Eliza Hall Institute For Medical Research
Curated by ChEMBL
Affinity DataEC50: 220nMAssay Description:Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HDAC5 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 226nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HDAC7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 647nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human HDAC1 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cells using Ac-KGLGK(Ac)-MCA as substrate incubated for 30 mins in presence of 0.1 mM DTT by fluorescence...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Displacement of [3H]-acetylated histones from mouse HDAC6 transfected in HEK-293T cells incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]-acetylated histones from human HDAC1 transfected in HEK-293T cells incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Displacement of [3H]-acetylated histones from human HDAC2 transfected in HEK-293T cells incubated for 15 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human HDAC1 expressed in HEK293T cells by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human HDAC2 expressed in HEK293T cells by scintillation counting analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of human HDAC4 expressed in HEK293T cells by scintillation counting analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human HDAC6 expressed in HEK293T cells by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC1 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of HDAC2 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC3 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of HDAC6 in human DU-145 cells assessed as increase in histone H3 acetylation after 24 hrs by immunofluorescence microscopyMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Mus musculus)
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Tohoku Medical And Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.625nMAssay Description:Inhibition of mouse HDAC6 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate reader in presence of 0.1 mM dithiothreito...More data for this Ligand-Target Pair