BDBM50049478 1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl}-1-oxopropan-2-yl]carbamoyl}-1-methylethan-1-aminium::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide [3a(MK-0677)]::1N-[1-benzyloxymethyl-2-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-2-oxo-(1R)-ethyl]-2-amino-2-methylpropanamide(MK-0677)::CHEMBL13817::MK 0677::MK-0677::MK-677
SMILES CC(C)(C(=O)N[C@H](COCc1ccccc1)C(=O)N2CCC3(CC2)CN(c4c3cccc4)S(=O)(=O)C)N
InChI Key InChIKey=UMUPQWIGCOZEOY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50049478
Affinity DataIC50: 0.400nMAssay Description:Inhibition against human growth hormone secretagogue (GHS) receptorMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2nMAssay Description:Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.400nMAssay Description:Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.398nMAssay Description:Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Agonist activity at human GHS-R1More data for this Ligand-Target Pair
Affinity DataEC50: 1.40nMAssay Description:Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aMore data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 0.510nMAssay Description:Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:In vitro growth hormone release was determined in rat pituitary cell assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.140nMAssay Description:Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityMore data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 8.90nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1/Isoform 1B of Growth hormone secretagogue receptor type 1 (1B)(Human)
Université Montpellier 1
Université Montpellier 1
Affinity DataKi: 9.90nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
Affinity DataKi: 10.2nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
Affinity DataKi: 65.8nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
Affinity DataKi: 68.4nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
Affinity DataKi: 68.9nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1/Isoform 1B of Growth hormone secretagogue receptor type 1 (1B)(Human)
Université Montpellier 1
Université Montpellier 1
Affinity DataKi: 90.6nMAssay Description:Briefly, direct ligand binding experiments were performed using fluorescence energy transfer with the purified receptor labeled with Alexa Fluor 350 ...More data for this Ligand-Target Pair