BDBM50050527 Boronic acid derivative::CHEMBL66032::US11096924, DASH-inhibitors 5466::US11559537, Compound 5466

SMILES CC[C@H](N)C(=O)N1CCC[C@H]1B(O)O

InChI Key InChIKey=PHCFSFBQEROREL-BQBZGAKWSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50050527   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  11nMAssay Description:In vitro for inhibition of Dipeptidylpeptidase IV.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  440nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  6.00E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  900nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  2.90E+3nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  4.20E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHomeobox protein PKNOX1(Human)
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  3.80E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8/9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  4.40E+5nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  23nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  6nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  0.900nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  2.90nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  42nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProlyl endopeptidase(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  380nMAssay Description:This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Trustees of Tufts College

US Patent
LigandPNGBDBM50050527(Boronic acid derivative | CHEMBL66032 | US11096924...)
Affinity DataIC50:  2.30E+4nMAssay Description:EnzymesRecombinant human DPPIV (R&D Systems, Cat. No. 1180-SE)Recombinant human DPP8 (Enzo Life Sciences, Cat. No. BML-SE527)Recombinant human DPP9 (...More data for this Ligand-Target Pair
In DepthDetails US Patent