BDBM50050917 CHEMBL42539::[2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3-p-tolyl-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amine

SMILES COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccc(C)cc1

InChI Key InChIKey=UNHGFWKSHHCRHF-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50050917   

TargetAlpha-1A adrenergic receptor(CALF)
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity of the compound towards Alpha-1A adrenergic receptor in bovine brain using [3H]-prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  4.10nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  5.32nMAssay Description:Binding affinity of the compound towards Alpha-1A adrenergic receptor in rat hipocamous (+ 10 uM) CES membrane using [3H]-prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  11.8nMAssay Description:Binding affinity of the compound towards Alpha-1D adrenergic receptor in rat brain using [3H]-prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  51.4nMAssay Description:Binding affinity of the compound towards Alpha-1B adrenergic receptor hamster smooth muscle using [3H]-prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  82.3nMAssay Description:In vitro inhibitory activity of the compound against [3H]-raclopride binding to Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  103nMAssay Description:Binding affinity of the compound towards Alpha-1B adrenergic receptor in rat liver using [3H]-prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50050917(CHEMBL42539 | [2-(2,6-Dimethoxy-phenoxy)-ethyl]-(3...)
Affinity DataKi:  606nMAssay Description:Binding affinity of the compound towards 5-hydroxytryptamine 1A receptor in rat hypocampus membrane using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed