BDBM50052593 3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine::3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-yl)-pyridine::Altinicline::CHEMBL111659::US10667515, Compound (S)-SIB 1508Y

SMILES CN1CCC[C@H]1c1cncc(c1)C#C

InChI Key InChIKey=NUPUDYKEEJNZRG-LBPRGKRZSA-N

Data  1 IC50  13 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50052593   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  1.80E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  1.80E+3nMAssay Description:The compound was tested on recombinant human alpha-1-beta-1-gamma-delta cell lines of human embryonic kidney for nicotinic acetylcholine receptor ago...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataIC50:  8.90E+3nMAssay Description:The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  5.00E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  5.00E+3nMAssay Description:The compound was tested on recombinant human alpha2-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  2.30E+4nMAssay Description:The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  2.30E+4nMAssay Description:The compound was tested on recombinant human alpha3-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-4(Homo sapiens (Human))
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)
Affinity DataEC50:  9.00E+3nMAssay Description:The compound was tested on recombinant human alpha4-beta4 cell lines of Human embryonic kidney for nicotinic acetylcholine receptor agonist functiona...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed