BDBM50056938 2,6,7-Trihydroxy-9-methyl-xanthen-3-one::CHEMBL175266::NSC-66209::US20230364057, Compound 75::cid_72721

SMILES Cc1c2cc(O)c(O)cc2oc2cc(=O)c(O)cc12

InChI Key InChIKey=TZVNNUHRZXQCHM-UHFFFAOYSA-N

Data  17 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50056938   

TargetEphrin type-B receptor 4(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  3.60E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDNA gyrase inhibitor()
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  5.28E+3nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  5.38E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGlycoprotein 42(Human herpesvirus 4 type 2)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  990nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataEC50:  3.00E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataEC50:  4.02E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03MH084830-01 Project Title: TR-FRET HTS Assay for Inhibitors of MEKK2-MEK5 PB1 Domain...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPOsterior Segregation(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataEC50:  1.90E+3nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetZinc finger protein mex-5(Caenorhabditis elegans)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataEC50:  82nMAssay Description:Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  5.40E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMannose-6-phosphate isomerase(Homo sapiens (Human))
Sanford-Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  3.55E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  835nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPC4 and SFRS1-interacting protein(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  1.54E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetPC4 and SFRS1-interacting protein(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  212nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: Ohio State University Assay Provider: Mam...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration of compound against strand transfer of of HIV-2 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  900nMAssay Description:Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdTDP-4-dehydrorhamnose reductase(Mycobacterium tuberculosis)
University Of California

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis RmlD assessed as inhibition of dTDP-beta-6-deoxy-L-lyxo-4-hexulose to dTDP-beta-L-rhamnose conversionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 2)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-2 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4 gamma 1(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50056938(2,6,7-Trihydroxy-9-methyl-xanthen-3-one | CHEMBL17...)
Affinity DataIC50:  4.33E+4nMAssay Description:Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay