BDBM50057511 (+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9-methyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one::(-)-indolactam V::(10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4(15),5,7-tetraen-11-one::(10S,13S)-13-Hydroxymethyl-10-isopropyl-9-methyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one::(2S,5S)-5-(hydroxymethyl)-2-isopropyl-1-methyl-1,2,5,6-tetrahydro-4H-[1,4]diazonino[7,6,5-cd]indol-3(8H)-one::(S)-13-Hydroxymethyl-10-isopropyl-9-(S)-methyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one::13-Hydroxymethyl-10-isopropyl-9-methyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4(15),5,7-tetraen-11-one::13-Hydroxymethyl-10-isopropyl-9-methyl-3,9,12-triaza-tricyclo[6.6.1.0*4,15*]pentadeca-1,4,6,8(15)-tetraen-11-one(ILV)::CHEMBL27266::INDOLACTUM::indolactam-V

SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23

InChI Key InChIKey=LUZOFMGZMUZSSK-LRDDRELGSA-N

Data  70 KI  1 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50057511   

TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  2.01nMAssay Description:Binding of Indolactam-V(ILV) to wild-type Protein kinase C delta C1b domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  2.01nMAssay Description:Displacement of [3H]- PDBu from Protein kinase C delta C1b domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  2.01nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain (Wild type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAS guanyl-releasing protein 1(Rattus norvegicus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  2.54nMAssay Description:Binding affinity against RAS guanyl releasing protein using [3H]- PDBu as the labeled ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC beta expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  8.20nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC delta expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  10.9nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (F13G)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  10.9nMAssay Description:Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Phe13 to Gly)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC alpha expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  19.4nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC gamma expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  21.9nMAssay Description:Displacement of [3H]- PDBu from recombinant PKC epsilon expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  25.3nMAssay Description:Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Thr12 to Gly)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  25.3nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (T12G)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  66.2nMAssay Description:Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Leu20 to Gly)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  66.2nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (L20G)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  658nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (T8G)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  658nMAssay Description:Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Tyr8 to Gly)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (Q27V)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Gln27 to Val)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  7.08E+3nMAssay Description:Binding of Indolactam-V(ILV) to mutant Protein kinase C delta C1b domain (Pro11 to Gly)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Mus musculus)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50057511((+/-)-indolactum-V 13-Hydroxymethyl-10-isopropyl-9...)
Affinity DataKi:  7.08E+3nMAssay Description:Displacement of [3H]-PDBu from protein kinase C delta C1b domain mutant (P11G)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed