BDBM50057544 4-[5-(3,5-Dichloro-4-methoxy-phenyl)-3-difluoromethyl-pyrazol-1-yl]-benzenesulfonamide::CHEMBL287646

SMILES COc1c(Cl)cc(cc1Cl)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)F

InChI Key InChIKey=ATGNWRJVESLUOP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50057544   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50057544(4-[5-(3,5-Dichloro-4-methoxy-phenyl)-3-difluoromet...)
Affinity DataIC50:  7.70E+4nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50057544(4-[5-(3,5-Dichloro-4-methoxy-phenyl)-3-difluoromet...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50057544(4-[5-(3,5-Dichloro-4-methoxy-phenyl)-3-difluoromet...)
Affinity DataIC50:  7.76E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50057544(4-[5-(3,5-Dichloro-4-methoxy-phenyl)-3-difluoromet...)
Affinity DataIC50:  20.9nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50057544(4-[5-(3,5-Dichloro-4-methoxy-phenyl)-3-difluoromet...)
Affinity DataIC50:  20.9nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed