BDBM50060763 CHEMBL3394741::US9458172, 61
SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3o2)nc1
InChI Key InChIKey=DZFCBWGZQNGTQH-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50060763
Affinity DataIC50: 6.5nMpH: 7.5Assay Description:The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of human C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta(DE3) incubated for 15 mins prior to substrate addition measure...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomes using midazolam as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Reversible inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair