BDBM50060764 CHEMBL3394740::US9458172, 45

SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cc3ccncc3s2)nc1

InChI Key InChIKey=KUXPZTAQCRKPDT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50060764   

TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50060764(CHEMBL3394740 | US9458172, 45)
Affinity DataIC50:  7nMAssay Description:Inhibition of human C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta(DE3) incubated for 15 mins prior to substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50060764(CHEMBL3394740 | US9458172, 45)
Affinity DataIC50:  7.20nMpH: 7.5Assay Description:The NAMPT Enzymatic Reaction. The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) i...More data for this Ligand-Target Pair
In DepthDetails US Patent