BDBM50061884 8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bicyclo[3.2.1]octane::CHEMBL417249

SMILES Fc1ccc(cc1)C(OC1CC2CCC(C1)N2CC=C)c1ccc(F)cc1

InChI Key InChIKey=WDOKGNOTOAMJEX-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50061884   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition of dopamine uptake in rat tissue, was determined using [3H]-DAU as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  29.9nMAssay Description:Displacement of [3H]WIN-35428 from the dopamine transporter in rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-WIN- 35, 428 from the dopamine transporter in rat caudate putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  126nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor M1 sites of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  130nMAssay Description:Binding affinity at dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  177nMAssay Description:Binding affinity at Muscarinic acetylcholine receptor M1 in Rat brain homogenate by [3H]pirenzepine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  1.45E+3nMAssay Description:Compound is evaluated for binding to Serotonin transporter using [3H]-Citalopram as radioligand in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50061884(8-Allyl-3-[bis-(4-fluoro-phenyl)-methoxy]-8-aza-bi...)
Affinity DataKi:  5.92E+3nMAssay Description:Compound was evaluated for binding to Norepinephrine Transporter (NET) using [3H]-desmethylimipramine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed