BDBM50064176 CHEMBL27673::CHEMBL500996::METHOCTRAMINE::N,N''-Bis-[6-(2-methoxy-benzylamino)-hexyl]-octane-1,8-diamine::N1,N8-bis(6-(2-methoxybenzylamino)hexyl)octane-1,8-diamine

SMILES COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC

InChI Key InChIKey=RPMBYDYUVKEZJA-UHFFFAOYSA-N

Data  71 KI  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50064176   

TargetMuscarinic acetylcholine receptor M2(RAT)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  34nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  5.37E+3nMAssay Description:Inhibitory activity on Acetylcholinesterase (AChE) from human erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  5.37E+3nMAssay Description:Inhibition of acetylcholinesterase (AChE) of human erythrocytesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]AF-DX 384 from human recombinant M2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Chiba University

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  138nMAssay Description:Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/gluta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]AF-DX384 from human recombinant muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Bologna

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  977nMAssay Description:Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064176(CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed