BDBM50064896 4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chromen-7-one::5,7-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chromen-4-one::5,7-dihydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one::CHEMBL78010::NSC-106403::Pectolinarigenin::cid_5320438

SMILES COc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1

InChI Key InChIKey=GPQLHGCIAUEJQK-UHFFFAOYSA-N

Data  1 KI  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50064896   

TargetDelta-type opioid receptor(Homo sapiens (Human))
University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataKi:  8.40E+3nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor (unknown origin) transfected into HEK293 cells by microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls University of Tuebingen

LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50:  3.24E+4nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Sejong University

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50:  600nMAssay Description:Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Chinese University of Hong Kong (Shenzhen)

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50:  650nMAssay Description:Inhibition of recombinant His-tagged human FLT3 (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substrate incubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Chinese University of Hong Kong (Shenzhen)

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50:  880nMAssay Description:Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in Sf9 insect cells incubated for 1 hr by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Chinese University of Hong Kong (Shenzhen)

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50:  580nMAssay Description:Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system using tyr 02 as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataEC50:  2.29E+3nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Sejong University

Curated by ChEMBL
LigandPNGBDBM50064896(4,5-Dihydroxy-6-methoxy-2-(4-methoxy-phenyl)-chrom...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of wild type His-tagged c-KIT (544 to 976 amino acids) (unknown origin) expressed in insect cells using poly[Glu:Tyr] (4:1) as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed